InsiderSource
SEPN

Septerna, Inc.

SEC CIK 1984086
$34.03 +33.2% · 90 days
90-day buys
$0
0 open-market
90-day sells
$623.7K
7 open-market
Net insider flow
−$623.7K
Net selling
Filings shown
24
Most recent
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At a glance

Over the last 90 days, insiders at SEPN have sold a net $623.7K of stock (0 open-market buys vs 7 sells).

Largest recent trade: Shaikhly Samira sold $1.87M of SEPN, trimming their stake 99%.

Most active filer: Shaikhly Samira, with 13 transactions among the recent filings shown.

Insider transaction history

Form 4 filings for SEPN, newest first
View on SEC EDGAR ↗
SEPN
Septerna, Inc.
Option exercise Shaikhly Samira · Chief People Officer · Option exercise · filed 1w ago ΔOwn +549%
+$6.8K
4,355 sh @ $2
SEPN
Septerna, Inc.
Sell Shaikhly Samira · Chief People Officer · Open-market sale · filed 1w ago ΔOwn −25%

Shaikhly Samira sold $47.2K of SEPN, trimming their stake 25%.

−$47.2K
1,700 sh @ $28
SEPN
Septerna, Inc.
Sell Shaikhly Samira · Chief People Officer · Open-market sale · filed 1w ago ΔOwn −27%

Shaikhly Samira sold $38.8K of SEPN, trimming their stake 27%.

−$38.8K
1,346 sh @ $29
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SEPN
Septerna, Inc.
Sell Shaikhly Samira · Chief People Officer · Open-market sale · filed 1w ago ΔOwn −78%

Shaikhly Samira sold $85.7K of SEPN, trimming their stake 78%.

−$85.7K
2,889 sh @ $30
SEPN
Septerna, Inc.
Option exercise Shaikhly Samira · Chief People Officer · Option exercise · filed 2w ago ΔOwn +999%
+$80.3K
11,798 sh @ $7
SEPN
Septerna, Inc.
Sell Shaikhly Samira · Chief People Officer · Open-market sale · filed 2w ago ΔOwn −94%

Shaikhly Samira sold $354.7K of SEPN, trimming their stake 94%.

−$354.7K
11,798 sh @ $30
SEPN
Septerna, Inc.
Option exercise Bhatt Elizabeth · President and COO · Option exercise · filed Apr 17, 2026 ΔOwn +2.3%
+$27.2K
4,000 sh @ $7
SEPN
Septerna, Inc.
Sell Bhatt Elizabeth · President and COO · Open-market sale · filed Apr 17, 2026 ΔOwn −1.4%

Bhatt Elizabeth sold $61.1K of SEPN, trimming their stake 1%.

−$61.1K
2,573 sh @ $24
SEPN
Septerna, Inc.
Sell Bhatt Elizabeth · President and COO · Open-market sale · filed Apr 17, 2026 ΔOwn −0.6%

Bhatt Elizabeth sold $27.8K of SEPN, trimming their stake 1%.

−$27.8K
1,101 sh @ $25
SEPN
Septerna, Inc.
Sell Bhatt Elizabeth · President and COO · Open-market sale · filed Apr 17, 2026 ΔOwn −0.2%

Bhatt Elizabeth sold $8.4K of SEPN.

−$8.4K
326 sh @ $26
SEPN
Septerna, Inc.
Option exercise Shaikhly Samira · Chief People Officer · Option exercise · filed Mar 4, 2026 ΔOwn +999%
+$83.3K
53,714 sh @ $2
SEPN
Septerna, Inc.
Option exercise Shaikhly Samira · Chief People Officer · Option exercise · filed Mar 4, 2026 ΔOwn +21%
+$32.1K
11,638 sh @ $3
SEPN
Septerna, Inc.
Option exercise Shaikhly Samira · Chief People Officer · Option exercise · filed Mar 4, 2026 ΔOwn +7.7%
+$14.1K
5,101 sh @ $3
SEPN
Septerna, Inc.
Sell Shaikhly Samira · Chief People Officer · Open-market sale · filed Mar 4, 2026 ΔOwn −5.7%

Shaikhly Samira sold $112.5K of SEPN, trimming their stake 6%.

−$112.5K
4,090 sh @ $28
SEPN
Septerna, Inc.
Sell Shaikhly Samira · Chief People Officer · Open-market sale · filed Mar 4, 2026 ΔOwn −99%

Shaikhly Samira sold $1.87M of SEPN, trimming their stake 99%.

−$1.87M
66,363 sh @ $28
SEPN
Septerna, Inc.
Option exercise Bhatt Elizabeth · President and COO · Option exercise · filed Feb 20, 2026 ΔOwn +2.3%
+$27.2K
4,000 sh @ $7
SEPN
Septerna, Inc.
Sell Bhatt Elizabeth · President and COO · Open-market sale · filed Feb 20, 2026 ΔOwn −1.2%

Bhatt Elizabeth sold $62.6K of SEPN, trimming their stake 1%.

−$62.6K
2,200 sh @ $28
SEPN
Septerna, Inc.
Sell Bhatt Elizabeth · President and COO · Open-market sale · filed Feb 20, 2026 ΔOwn −1.0%

Bhatt Elizabeth sold $53.2K of SEPN, trimming their stake 1%.

−$53.2K
1,800 sh @ $30
SEPN
Septerna, Inc.
Sell Long Daniel D. · SVP, Drug Discovery · Open-market sale · filed Nov 13, 2025 ΔOwn −3.6%

Long Daniel D. sold $63.2K of SEPN, trimming their stake 4%.

−$63.2K
3,501 sh @ $18
SEPN
Septerna, Inc.
Option exercise Klein Uwe · SVP, Biological Sciences · Option exercise · filed Aug 19, 2025 ΔOwn NEW
+$28.8K
10,452 sh @ $3
SEPN
Septerna, Inc.
Option exercise Klein Uwe · SVP, Biological Sciences · Option exercise · filed Aug 19, 2025 ΔOwn +47%
+$13.6K
4,935 sh @ $3
SEPN
Septerna, Inc.
Option exercise Klein Uwe · SVP, Biological Sciences · Option exercise · filed Aug 19, 2025 ΔOwn +50%
+$51.9K
7,621 sh @ $7
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About SEPN insider activity

This page tracks every recent Form 4 filed for Septerna, Inc. with the U.S. Securities and Exchange Commission. Form 4 is the disclosure that company insiders — officers, directors, and holders of more than 10% of the stock — must file within two business days of buying or selling shares.

The summary above nets open-market purchases against open-market sales over the trailing 90 days. Open-market trades (codes P and S) tend to carry the most signal because they reflect a deliberate choice to put money in or take it out, as opposed to routine grants, option exercises, or tax-withholding events. Use the badges on each row to tell them apart, and always confirm details against the original filing before drawing conclusions.

Frequently asked questions

How often is SEPN insider data updated?

Continuously. We read from SEC EDGAR, so new Form 4 filings for Septerna, Inc. usually appear here within minutes of being accepted by the SEC.

What does "net insider flow" mean?

It is the total dollar value of open-market insider purchases minus open-market sales over the last 90 days. A positive number (green) means insiders bought more than they sold; a negative number (red) means the reverse.

Why do some rows show grants or option exercises instead of buys?

Insiders receive stock through compensation as well as buying it outright. Form 4 captures all of these. We label each transaction by its SEC code so you can focus on open-market activity if you prefer.

Is this investment advice?

No. InsiderSource presents public filing data for informational purposes only. Insider activity is one of many factors to consider and is never a recommendation to buy or sell.